Important Information You Need to Know Before Injecting PTG-300

• Read all the instructions for use below before beginning the preparation and injection of PTG-300.
• Use only the supplies provided with the drug kit.
• Do not use if the kit is expired or if any of the supplies are opened, damaged or missing. Contact the Clinical Site.
• Remove the kit from the refrigerator at least 15 minutes before you start preparing to allow it to warm to room temperature.
• You will need a Sharps Container and alcohol swabs (provided by Clinical Site) in addition to your drug kit, each time you inject.
• Do not touch the grey rubber stopper on the top of the vial.
• Do not let the syringe tip or needle touch your hands or any surface.
• Inject drug within 4 hours of mixing it.
• For subcutaneous injection only (inject directly into the fatty layer just under the skin).
• Refer to the Disposing of Rusfertide (PTG-300) section on how to properly dispose of or return used supplies from the kit, including safe handling. All supplies are for single use only.
• Return unused drug vials to the clinical site.